Mammalian collagen receptors

被引：295

作者：

Leitinger, Birgit

Hohenester, Erhard ^{[1
]}

机构：

[1] Imperial Coll London, Blackett Lab, Biophys Sect, Div Cell & Mol Biol, London SW7 2AZ, England

[2] Imperial Coll London, Natl Heart & Lung Inst, London SW7 2AZ, England

来源：

MATRIX BIOLOGY | 2007年 / 26卷 / 03期

基金：

英国惠康基金;

关键词：

collagen; triple helix; integrin; receptor tyrosine kinase; cell adhesion; hemostasis;

D O I：

10.1016/j.matbio.2006.10.007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Collagen-rich extracellular matrices are abundant and ubiquitous in the mammalian body. Collagens are not only essential for the mechanical stability of tissues, but are also intimately involved in controlling cell behaviour. The hallmark of collagens is a triple helix made up of polypeptide chains containing glycine-X-Y repeats. A structurally and functionally diverse group of cell surface receptors mediates the recognition of triple-helical collagen: integrins, discoidin domain receptors, glycoprotein VI, leukocyte-associated IG-like receptor-1, and members of the mannose receptor family. In this review, we discuss the structure and function of these receptors, focussing on the principles involved in collagen recognition. (c) 2006 Elsevier B.V./Intemational Society of Matrix Biology. All rights reserved.

引用

收藏

页码：146 / 155

页数：10

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