Ivermectin - Old Drug, New Tricks?

被引：276

作者：

Laing, Roz ^{[1
]}

Gillan, Victoria ^{[1
]}

Devaney, Eileen ^{[1
]}

机构：

[1] Univ Glasgow, Inst Biodivers Anim Hlth & Comparat Med, Garscube Estate, Glasgow G61 1QH, Lanark, Scotland

来源：

TRENDS IN PARASITOLOGY | 2017年 / 33卷 / 06期

基金：

英国生物技术与生命科学研究理事会;

关键词：

GATED CHLORIDE CHANNEL; MACROCYCLIC LACTONE RESISTANCE; HAEMONCHUS-CONTORTUS; ONCHOCERCA-VOLVULUS; AVERMECTIN; EFFICACY; PARASITE; POTENT; GENE; MICROFILARIAE;

D O I：

10.1016/j.pt.2017.02.004

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

090105 [作物生产系统与生态工程]; 100103 [病原生物学];

摘要：

Ivermectin is one of the most important drugs in veterinary and human medicine for the control of parasitic infection and was the joint focus of the 2015 Nobel Prize in Physiology or Medicine, some 35 years after its remarkable discovery. Although best described for its activity on glutamate-gated chloride channels in parasitic nematodes, understanding of its mode of action remains incomplete. In the field of veterinary medicine, resistance to ivermectin is now widespread, but the mechanisms underlying resistance are unresolved. Here we discuss the history of this versatile drug and its use in global health. Based on recent studies in a variety of systems, we question whether ivermectin could have additional modes of action on parasitic nematodes.

引用

页码：463 / 472

页数：10

共 76 条

[1]

Ivermectin lacks antituberculous activity [J].