Insulin-like growth factor binding protein-1 levels are increased in patients with IgA nephropathy

被引：18

作者：

Tokunaga, Koki ^{[1
]}

Uto, Hirofumi ^{[1
]}

Takami, Yoichiro ^{[1
]}

Mera, Kumiko ^{[1
]}

Nishida, Chika ^{[1
]}

Yoshimine, Yozo ^{[1
]}

Fukumoto, Mayumi ^{[1
]}

Oku, Manei ^{[1
]}

Sogabe, Atsushi ^{[1
]}

Nosaki, Tsuyoshi ^{[1
]}

Moriuchi, Akihiro ^{[1
]}

Oketani, Makoto ^{[1
]}

Ido, Akio ^{[1
]}

Tsubouchi, Hirohito ^{[1
]}

机构：

[1] Kagoshima Univ, Grad Sch Med & Dent Sci, Dept Digest & Life Style Related Dis, Hlth Res Course, Kagoshima 8908520, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 399卷 / 02期

关键词：

IGFBP-1; IgA nephropathy; Serum level; Mesangial cell proliferation; IGF-1; CHRONIC-RENAL-FAILURE; FACTOR-I; FACTOR SYSTEM; EXTRACELLULAR-MATRIX; CELL-PROLIFERATION; DIABETES-MELLITUS; GENE-EXPRESSION; SERUM; HORMONE; KIDNEY;

D O I：

10.1016/j.bbrc.2010.07.032

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The mechanisms underlying the pathogenesis of immunoglobulin A (IgA) nephropathy (IgAN) are not well understood. In this study, we examined gene expression profiles in kidneys obtained from mice with high serum IgA levels (HIGA mice), which exhibit features of human IgAN. Female inbred HIGA, established from the ddY line, were used in these experiments. Serum IgA levels, renal IgA deposition, mesangial proliferation, and glomerulosclerosis were increased in 32-week-old HIGA mice in comparison to ddY animals. By microarray analysis, five genes were observed to be increased by more than 2.5-fold in 32-week-old HIGA in comparison to 16-week-old HIGA; these same five genes were decreased more than 2.5-fold in 32-week-old ddY in comparison to 16-week-old ddY mice. Of these five genes, insulin-like growth factor (IGF) binding protein (IGFBP)-1 exhibited differential expression between these mouse lines, as confirmed by quantitative RT-PCR. In addition, serum IGFBP-1 levels were significantly higher in patients with IgAN than in healthy controls. In patients with IgAN, these levels correlated with measures of renal function, such as estimated glomerular filtration rate (eGFR), but not with sex, age, serum IgA, C3 levels, or IGF-1 levels. Pathologically, serum IGFBP-1 levels were significantly associated with the severity of renal injury, as assessed by mesangial cell proliferation and interstitial fibrosis. These results suggest that increased IGFBP-1 levels are associated with the severity of renal pathology in patients with IgAN. (c) 2010 Elsevier Inc. All rights reserved.

引用

页码：144 / 149

页数：6

共 34 条

[21] Enhanced production of glomerular extracellular matrix in a new mouse strain of high serum IgA ddY mice [J].