Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells

被引：51

作者：

Hsu, YL

Kuo, PL

Lin, LT

Lin, CC

机构：

[1] Kaohsiung Med Univ, Coll Pharm, Grad Inst Nat Prod, Kaohsiung 807, Taiwan

[2] Chia Nan Univ Pharm & Sci, Dept Biotechnol, Tainan, Taiwan

[3] McGill Univ, Dept Microbiol & Immunol, Montreal, PQ, Canada

来源：

PLANTA MEDICA | 2005年 / 71卷 / 02期

关键词：

isoliquiritigenin; apoptosis; caspase I; I kappa B alpha; NF-kappa B;

D O I：

10.1055/s-2005-837779

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Isoliquiritigenin (4,2 ',4 ' -trihydroxychalcone, ISL) is a natural pigment with a simple chalcone structure. In this study, we report the ISL-induced inhibition on the growth of human hepatoma cells (Hep G2) for the first time. The cell growth inhibition achieved by ISL treatment resulted in programmed cell death in a caspase activation-dependent manner, with an IC50 of 10.51 mu g/mL. Outcomes of ISL treatment included the up-regulation of I kappa B alpha expression in the cytoplasm, and the decrease of NF-kappa B level as well as its activity in the nucleus. In addition, ISL also suppressed the expression of Bcl-X-L and c-IAP1/2 protein, the downstream target molecule of NF-kappa B. These results demonstrated that ISL treatment inhibited the NF-kappa B cell survival-signaling pathway and induced apoptotic cell death in Hep G2 cells.

引用

页码：130 / 134

页数：5

共 16 条

[1] Studies on cancer chemoprevention by traditional folk medicines XXV. Inhibitory effect of isoliquiritigenin on azoxymethane-induced murine colon aberrant crypt focus formation and carcinogenesis [J].