Strategy for analysis and screening of bioactive compounds in traditional Chinese medicines

被引：135

作者：

Huang, XD ^{[1
]}

Kong, LA ^{[1
]}

Li, X ^{[1
]}

Chen, XG ^{[1
]}

Guo, M ^{[1
]}

Zou, HF ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Natl Chromatog Res & Anal Ctr, Dalian 116011, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2004年 / 812卷 / 1-2期

关键词：

reviews; screening; bioactive compounds;

D O I：

10.1016/j.jchromb.2004.06.046

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Traditional Chinese medicines (TCMs), due to their long time clinic test and reliable therapeutic efficacy, are attracting increased global attention served as excellent pools of bioactive compounds for the discovery of new drugs. However, hundreds or even thousands of components are usually contained in traditional Chinese medicines and only a few compounds are responsible for the pharmaceutical and/or toxic effects. The large numbers of other components in traditional Chinese medicines make the screening and analysis of the bioactive components extremely difficult. By the way, the combination effect of bioactive components on the pharmacological activity makes it very difficult to clear the therapeutic mechanism of TCMs. Therefore, some strategies have to design for screening of bioactive compounds in traditional Chinese medicines, which further leads to disclose the therapeutic mechanism of TCMs in molecular level. The review will summarize the present state of the art of screening strategy for active compounds in traditional Chinese medicines, and the chromatography methods for screening and analysis of bioactive compounds in traditional Chinese medicines will be emphasized. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：71 / 84

页数：14

共 88 条

[21]

Homma M, 1997, BIOMED CHROMATOGR, V11, P125, DOI 10.1002/(SICI)1099-0801(199705)11:3<125::AID-BMC631>3.0.CO

[22]

2-L

[23] A STRATEGY FOR DISCOVERING BIOLOGICALLY-ACTIVE COMPOUNDS WITH HIGH PROBABILITY IN TRADITIONAL CHINESE HERB REMEDIES - AN APPLICATION OF SAIBOKU-TO IN BRONCHIAL-ASTHMA [J].