Na+-Ca2+ exchanger isoforms in rat neuronal preparations:: different changes in their expression during postnatal development

被引：35

作者：

Sakaue, M

Nakamura, H

Kaneko, I

Kawasaki, Y

Arakawa, N

Hashimoto, H

Koyama, Y

Baba, A

Matsuda, T

机构：

[1] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Med Pharmacol, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Pharmaceut Sci, Lab Mol Neuropharmacol, Suita, Osaka 5650871, Japan

来源：

BRAIN RESEARCH | 2000年 / 881卷 / 02期

关键词：

Na+-Ca2+ exchanger; isoform; postnatal development;

D O I：

10.1016/S0006-8993(00)02808-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the relative amounts of Na+-Ca2+ exchanger (NCX) isoform mRNAs in cultured neurons, astrocytes and developmental rat brain. NCX1 transcript was predominant in neurons and astrocytes, but NCX2 transcript was about four-fold higher than NCX1 or NCX3 transcript in adult rat cortex. NCX2 transcript in the cortex increased markedly during postnatal development, whereas NCX1 and NCX3 transcripts decreased. Na+-dependent Ca-45(2+) uptake in the cortical homogenate increased significantly during postnatal development. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：212 / 216

页数：5

相关论文

共 25 条

[1] NA+/CA2+ EXCHANGE CURRENT-DENSITY IN CARDIAC MYOCYTES FROM RABBITS AND GUINEA-PIGS DURING POSTNATAL-DEVELOPMENT [J].

ARTMAN, M ;

ICHIKAWA, H ;

AVKIRAN, M ;

COETZEE, WA .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1995, 268 (04) :H1714-H1722

[2]

BOERTH SR, 1996, CARDIOVASC RES, V31, P145

[3] Thyroid control of sarcolemmal Na+/Ca2+ exchanger and SR Ca2+-ATPase in developing rat heart [J].

Cernohorsky, J ;

Kolar, F ;

Pelouch, V ;

Korecky, B ;

Vetter, R .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 1998, 275 (01) :H264-H273

[4] ANALYSIS OF CYTOKINE MESSENGER-RNA AND DNA - DETECTION AND QUANTITATION BY COMPETITIVE POLYMERASE CHAIN-REACTION [J].

GILLILAND, G ;

PERRIN, S ;

BLANCHARD, K ;

BUNN, HF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (07) :2725-2729

[5] DEVELOPMENTAL-CHANGE IN THE NERVE GROWTH-FACTOR ACTION FROM INDUCTION OF CHOLINE-ACETYLTRANSFERASE TO PROMOTION OF CELL-SURVIVAL IN CULTURED BASAL FOREBRAIN CHOLINERGIC NEURONS FROM POSTNATAL RATS [J].

HATANAKA, H ;

TSUKUI, H ;

NIHONMATSU, I .

DEVELOPMENTAL BRAIN RESEARCH, 1988, 39 (01) :85-95

[6]

He SW, 1998, J NEUROSCI, V18, P4833

[7]

Hosoi R, 1997, J NEUROCHEM, V69, P2189

[8] Sodium-calcium exchange: Recent advances [J].

Hryshko, LV ;

Philipson, KD .

BASIC RESEARCH IN CARDIOLOGY, 1997, 92 (Suppl 1) :45-51

[9] Localization of the Na+-Ca2+ exchanger in vascular smooth muscle, and in neurons and astrocytes [J].

Juhaszova, M ;

Shimizu, H ;

Borin, ML ;

Yip, RK ;

Santiago, EM ;

Lindenmayer, GE ;

Blaustein, MP .

SODIUM-CALCIUM EXCHANGE: PROCEEDINGS OF THE THIRD INTERNATIONAL CONFERENCE, 1996, 779 :318-335

[10] REGULATION OF THE GLIAL FIBRILLARY ACIDIC PROTEIN, BETA-ACTIN AND PRION PROTEIN MESSENGER-RNAS DURING BRAIN-DEVELOPMENT IN MOUSE [J].

LAZARINI, F ;

DESLYS, JP ;

DORMONT, D .

MOLECULAR BRAIN RESEARCH, 1991, 10 (04) :343-346