The role of sphingosine and ceramide kinases in inflammatory responses

被引：83

作者：

Baumruker, T ^{[1
]}

Bornancin, F ^{[1
]}

Billich, A ^{[1
]}

机构：

[1] Novartis Inst BioMed Res Vienna, A-1235 Vienna, Austria

来源：

IMMUNOLOGY LETTERS | 2005年 / 96卷 / 02期

关键词：

ceramide kinase; immune cells; signalling; inflammation; sphingosine kinase;

D O I：

10.1016/j.imlet.2004.09.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

The 1-phosphates of sphingosine and ceramide (S1P and C1P) have emerged as key representatives of a new group of lipid signalling molecules. S1P is known to act both as an extracellular mediator and as an intracellular 'second messenger,' while C1P currently is only known for its intracellular actions. Therefore, sphingosine and ceramide kinases, the enzymes involved in the generation of these lipid mediators, are now in the spotlight. This review summarizes current information on structure, localization, substrate specificity, activation, and binding partners of these kinases, and then focuses on discoveries in relation to immune cell regulation and inflammation, addressing in particular mast cell activation and degranulation, IL-12 signalling, prostaglandin biosynthesis, monocyte activation, and neutrophil priming. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：175 / 185

页数：11

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