The emerging roles of human tissue kallikreins in cancer

被引：524

作者：

Borgoño, CA ^{[1
]}

Diamandis, EP ^{[1
]}

机构：

[1] Mt Sinai Hosp, Dept Pathol & Lab Med, Toronto, ON M5G 1X5, Canada

来源：

NATURE REVIEWS CANCER | 2004年 / 4卷 / 11期

关键词：

D O I：

10.1038/nrc1474

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human tissue kallikreins (hKs), which are encoded by the largest contiguous cluster of protease genes in the human genome, are secreted serine proteases with diverse expression patterns and physiological roles. Although primarily known for their clinical applicability as cancer biomarkers, recent evidence implicates hKs in many cancer-related processes, including cell-growth regulation, angiogenesis, invasion and metastasis. They have been shown to promote or inhibit neoplastic progression, acting individually and/or in cascades with other hKs and proteases, and might represent attractive targets for therapeutic intervention.

引用

页码：876 / 890

页数：15

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