Treatment of advanced mycosis fungoides by allogeneic stem-cell transplantation with a nonmyeloablative regimen

被引：45

作者：

Soligo, D

Ibatici, A

Berti, E

Morandi, P

Longhi, E

Venegoni, L

Corbellino, M

Annaloro, C

Robbiolo, L

Della Volpe, A

Alessi, E

Deliliers, GL

机构：

[1] Osped Maggiore Milano, IRCCS, Ctr Trapianti Midollo, Dept Hematol, I-20122 Milan, Italy

[2] Osped Maggiore Milano, IRCCS, Dept Dermatol, I-20122 Milan, Italy

[3] Osped Maggiore Milano, IRCCS, Transplantat Immunol & Blood Transfus Serv, I-20122 Milan, Italy

[4] Univ Milan, Inst Infect & Trop Dis, Milan, Italy

来源：

BONE MARROW TRANSPLANTATION | 2003年 / 31卷 / 08期

关键词：

mycosis fungoides; nonmyeloablative regimen; allogeneic stem cell transplantation; BONE-MARROW TRANSPLANTATION; SEZARY-SYNDROME; CHEMOTHERAPY; FLUDARABINE; LYMPHOMAS;

D O I：

10.1038/sj.bmt.1703872

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

Given the poor prognosis of patients with advanced cutaneous T-cell lymphoma and the high transplant-related mortality associated with conventional allogeneic bone marrow transplantation, we performed nonmyeloablative transplantation of allogeneic stem cells (ASCT) from HLA-identical siblings in three patients with this disease. All patients achieved full donor engraftment, clearance of clonal T cells leading to durable complete remissions but experienced high incidence of infections, which proved fatal in one case. These results suggest that nonmyeloablative ASCT is a novel and potentially curative therapy for patients with advanced T-cell lymphomas who have a histocompatible sibling.

引用

页码：663 / 666

页数：4

共 22 条

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