Predictive docking of protein-protein and protein-DNA complexes

被引：94

作者：

Sternberg, MJE ^{[1
]}

Gabb, HA ^{[1
]}

Jackson, RM ^{[1
]}

机构：

[1] Imperial Canc Res Fund, Biomol Modelling Lab, London WC2A 3PX, England

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1998年 / 8卷 / 02期

关键词：

D O I：

10.1016/S0959-440X(98)80047-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent developments in algorithms to predict the docking of two proteins have considered both the initial rigid-body global search and subsequent screening and refinement. The results of two blind trials of protein docking are encouraging - for complexes that are not too large and do not undergo sizeable conformational change upon association, the algorithms are now able to suggest reasonably accurate models.

引用

页码：250 / 256

页数：7

共 47 条

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