Predictive docking of protein-protein and protein-DNA complexes

被引:94
作者
Sternberg, MJE [1 ]
Gabb, HA [1 ]
Jackson, RM [1 ]
机构
[1] Imperial Canc Res Fund, Biomol Modelling Lab, London WC2A 3PX, England
关键词
D O I
10.1016/S0959-440X(98)80047-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent developments in algorithms to predict the docking of two proteins have considered both the initial rigid-body global search and subsequent screening and refinement. The results of two blind trials of protein docking are encouraging - for complexes that are not too large and do not undergo sizeable conformational change upon association, the algorithms are now able to suggest reasonably accurate models.
引用
收藏
页码:250 / 256
页数:7
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