Recombinant human interleukin-11 does not modify biochemical parameters of bone remodeling and bone mineral density in adult ovariectomized rats

被引：14

作者：

Verhaeghe, J

Van Herck, E

van Bree, R

Bouillon, R

Dequeker, J

Keith, JC

机构：

[1] Katholieke Univ Leuven, Dept Obstet & Gynecol, B-3001 Louvain, Belgium

[2] Katholieke Univ Leuven, Lab Expt Geneeskunde Endocrinol, B-3001 Louvain, Belgium

[3] Katholieke Univ Leuven, Arthrit & Metab Bone Dis Res Unit, B-3001 Louvain, Belgium

[4] Genet Inst Inc, Dept Preclin Res & Dev, Andover, MA USA

来源：

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH | 1998年 / 18卷 / 01期

关键词：

D O I：

10.1089/jir.1998.18.49

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Interleukin (IL)-11 stimulates osteoclast formation and inhibits osteoblast function in vitro and has been implicated in estrogen deficiency-induced bone loss. Herein we report the in vivo effect of recombinant human IL-11 (rHU-IL-11), administered s.c. in doses between 10 and 200 mu g/kg/day for 6 weeks into 6-month-old rats after ovariectomy, There was no difference between vehicle-treated and rHu-IL-11 treated rats in the ovariectomy-induced increase in the urinary excretion of pyridinoline and deoxypyridinoline. Neither was there a significant effect of rHu-IL-11 on the plasma concentrations of osteocalcin and on bone mineral density (BMD) measured at a metaphyseal area of the distal femur after 6 weeks. At all dosages tested, rHu-IL-11 increased the femoral diaphyseal area. In conclusion, IL-11 has no deleterious in vivo effect on biochemical parameters of bone remodeling and BMD in estrogen-deficient rats.

引用

页码：49 / 53

页数：5

共 26 条

[1] MECHANICAL-PROPERTIES, BONE-MINERAL CONTENT, AND BONE-COMPOSITION (COLLAGEN, OSTEOCALCIN, IGF-I) OF THE RAT FEMUR - INFLUENCE OF OVARIECTOMY AND NANDROLONE DECANOATE (ANABOLIC-STEROID) TREATMENT [J].