Transgenic methods for increasing Drosophila life span

被引：72

作者：

Tower, J ^{[1
]}

机构：

[1] Univ So Calif, Dept Sci Biol, Los Angeles, CA 90089 USA

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2000年 / 118卷 / 1-2期

关键词：

D O I：

10.1016/S0047-6374(00)00152-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

At least five different transgenic approaches have been applied to the study of Drosophila aging. There are two single component systems: transgenes with native (normal) promoters and transgenes with heterologous promoters; as well as three binary systems:'GAL4/UAS', 'FLP-out' and 'tet-on'. These approaches vary in ability to meet several technical challenges, and the relative advantages and disadvantages of each are discussed. Using these techniques, over-expression of the hsp70, Cu/ZnSOD and MnSOD genes has each been demonstrated to increase Drosophila life span. (C) 2000 Published by Elsevier Science Ireland Ltd.

引用

页码：1 / 14

页数：14

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