Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica

被引：58

作者：

Wang, LY ^{[1
]}

Unehara, T ^{[1
]}

Kitanaka, S ^{[1
]}

机构：

[1] Nihon Univ, Coll Pharm, Dept Pharmacognosy, Funabashi, Chiba 2748555, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2005年 / 53卷 / 01期

关键词：

Wikstroemia indica; Thymelaeaceae; guaiane; sesquiterpene; nitric oxide (NO); inducible nitric oxide synthase (iNOS);

D O I：

10.1248/cpb.53.137

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In our investigation of in vitro anti-allergic screening of medicinal herbal extracts, the ethyl acetate extract of the root of Wikstroemia indica was observed to inhibit nitric oxide (NO) production in a lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma) activated murine macrophage-like cell line, RAW 264.7. Fractionation of the active extract led to the isolation of one new guaiane type sesquiterpene, indicanone (1), and two known biflavonoids, sikokianin B (2) and sikokianin C (3). 1 inhibited NO production with IC50 values at 9.3 mum and also inhibit the inducible nitric oxide synhase (iNOS) gene expression. This is the first report of NO production inhibitory activity of Wikstroemia indica and supports the pharmacological use of it, which has been employed as an herbal medicine for the treatment of inflammation.

引用

页码：137 / 139

页数：3