Mammalian transglutaminases - Identification of substrates as a key to physiological function and physiopathological relevance

被引:153
作者
Esposito, C [1 ]
Caputo, I [1 ]
机构
[1] Univ Salerno, Dept Chem, I-84081 Baronissi, Italy
关键词
post-translational modification; protein substrates; proteomics; transglutaminase;
D O I
10.1111/j.1742-4658.2004.04476.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Transglutaminases form a large family of intracellular and extracellular enzymes that catalyse the Ca2+-dependent post-translational modification of proteins. Despite significant advances in our understanding of the biological role of most mammalian transglutaminase isoforms, recent findings suggest new scenarios, most notably for the ubiquitous tissue transglutaminase. It is becoming apparent that some transglutaminases, normally expressed at low levels in many tissue types, are activated and/or overexpressed in a variety of diseases, thereby resulting in enhanced concentrations of cross-linked proteins. As applies to all enzymes that exert their metabolic function by modifying the properties of target proteins, the identification and characterization of the modified proteins will cast light on the functions of transglutaminases and their involvement in human diseases. In this paper we review data on the properties of mammalian transglutaminases, particularly as regards their protein substrates and the relevance of transglutaminase-catalysed reactions in physiological and disease conditions.
引用
收藏
页码:615 / 631
页数:17
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