The genetics of cardiovascular disease: new insights from emerging approaches

被引：11

作者：

Chico, Timothy J. A. ^{[1
,2
]}

Milo, Marta ^{[2
]}

Crossman, David C. ^{[2
]}

机构：

[1] MRC Ctr Dev & Biomed Genet, Sheffield, S Yorkshire, England

[2] Sheffield Teaching Hosp NHS Trust, NIHR Cardiovasc Biomed Res Unit, Sheffield, S Yorkshire, England

来源：

JOURNAL OF PATHOLOGY | 2010年 / 220卷 / 02期

关键词：

microRNA; genome-wide association studies; deep sequencing; high-throughput sequencing; zebrafish; genetics; CORONARY-ARTERY-DISEASE; GENOME-WIDE ASSOCIATION; CARDIAC TROPONIN-T; ATRIAL-FIBRILLATION; MYOCARDIAL-INFARCTION; IN-VIVO; HYPERTROPHIC CARDIOMYOPATHY; MICRORNA EXPRESSION; CHROMOSOME; 9P21.3; HEART-DISEASE;

D O I：

10.1002/path.2641

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The prospect that sequencing the human genome would see rapid translation of a greater understanding of cardiovascular genetics into novel diagnostics and therapeutics has so far met with only limited success. However, diverse technological advances and exploitation of novel animal models of cardiovascular development and disease are providing ever more insight into cardiovascular diseases and development, and bring closer the prospect of 'post-genomic' diagnostics and therapies. Here we review some of these emerging approaches (genome wide association studies, deep sequencing, microRNA regulation, and zebrafish as a model of cardiovascular disease and development) and discuss their potential for finally fulfilling the promise of application to clinical cardiovascular medicine. Copyright (C) 2009 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

引用

页码：186 / 197

页数：12

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