Regio- and enantioselective carbolithiation of non-activated C=C bonds

被引：22

作者：

Norsikian, S ^{[1
]}

Baudry, M ^{[1
]}

Normant, JF ^{[1
]}

机构：

[1] Univ Paris 06, Associe CNRS, Lab Chim Organo Elements, F-75252 Paris 05, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 34期

关键词：

carbometalation; (-)-sparteine; enantioselection;

D O I：

10.1016/S0040-4039(00)01091-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Primary alkyllithiums in the presence of (-)-sparteine, add to terminal conjugated dienes. They also add to 2,4-pentadien-1-ols if they are substituted on C(5), and give rise to allyllithium intermediates, 2-Alkylalkan-1-ols have thus been prepared with ee's up to 74%. (C) 2000 Elsevier Science Ltd, All rights reserved.

引用

页码：6575 / 6578

页数：4