Coordinated regulation of the metabolome and lipidome at the host-microbial interface

被引:64
作者
Backhed, Fredrik [1 ,2 ]
Crawford, Peter A. [3 ]
机构
[1] Univ Gothenburg, Wallenberg Lab, Sahlgrenska Ctr Cardiovasc & Metab Res, S-41345 Gothenburg, Sweden
[2] Univ Gothenburg, Dept Mol & Clin Med, S-41345 Gothenburg, Sweden
[3] Washington Univ, Sch Med, Dept Med, Cardiovasc Res Ctr, St Louis, MO 63110 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2010年 / 1801卷 / 03期
基金
瑞典研究理事会;
关键词
Gut microbiota; Lipid metabolism; Obesity; DIET-INDUCED OBESITY; INFLAMMATORY BOWEL DISEASES; DISTAL GUT MICROBIOME; SERUM AMYLOID A3; GERM-FREE MICE; MOUSE MODEL; SYSTEMS BIOLOGY; GASTRIC BYPASS; ADIPOSE-TISSUE; INTESTINAL MICROBIOTA;
D O I
10.1016/j.bbalip.2009.09.009
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The creative use of gnotobiotic animals, coupled with the development of modern metagenomic sequencing platforms and metabolomic profiling of biospecimens, has bestowed new insight into the remarkably intricate interface between the host mammal and its resident microbiota. As mutual benefactors, each partner exhibits evidence of adaptation: the host provides a hospitable habitat, giving consideration to its own species of origin, diet, genotype, geographical location, presence or absence of disease, and use of medications; the microbiota, in turn, configures its constituency, collective genome (microbiome), transcriptome, and metabolome to optimally suit its ecological niche. In this review, we discuss the mechanisms through which the gut microbiota and its host collaborate to regulate lipid metabolism, thereby influencing the metabolic response to nutrient intake and ultimately, the development of obesity and associated diseases such as lipotoxicity. These studies therefore demonstrate that the gut microbiota is an "environmental" influence whose synergistic interdependence with its host strongly suggests that we are in fact "supraorganisms." (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:240 / 245
页数:6
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