Naphthalenebis[α,α-difluoromethylenephosphonates] as potent inhibitors of protein tyrosine phosphatases.

被引：43

作者：

Wang, QP

Huang, Z

Ramachandran, C

Dinaut, AN

Taylor, SD

机构：

[1] Univ Toronto, Erindale Coll, Dept Chem, Mississauga, ON L5L 1C6, Canada

[2] Merck Frosst Ctr Therapeut Res, Quebec City, PQ H9H 3L1, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(98)00027-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of naphthalenebis(difluoromethylenephosphonates) were prepared and compared to their monosubstituted counterparts as inhibitors of the protein phosphatases, PTP1B, CD45 and PP2A. In general, the bissubstituted compounds were better inhibitors than the mono derivatives and some of these are among the most potent, nonpeptidyl inhibitors of protein tyrosine phosphatases, PTP 1B and CD45, reported to date. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：345 / 350

页数：6

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