Recent advances in the use of DNA vaccines for the treatment of diseases of farmed animals

被引：39

作者：

Littel-van den Hurk, SV ^{[1
]}

Gerdts, V ^{[1
]}

Loehr, BI ^{[1
]}

Pontarollo, R ^{[1
]}

Rankin, R ^{[1
]}

Uwiera, R ^{[1
]}

Babiuk, LA ^{[1
]}

机构：

[1] Vet Infect Dis Org, Saskatoon, SK S7N 5E3, Canada

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2000年 / 43卷 / 01期

关键词：

veterinary DNA vaccines; farmed animals; delivery; immune responses; protection;

D O I：

10.1016/S0169-409X(00)00074-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

DNA-based vaccination constitutes one of the most recent approaches to vaccine development. This technology is in principle one of the most simple and yet versatile methods of inducing both humoral and cellular immune responses, as well as protection against a variety of infectious agents. However, although immune responses have been induced in a number of larger species, most information on the efficacy of DNA immunization has been generated in mice. In this review the information available to date about the use of DNA vaccines in farmed animals, including cattle, pigs and poultry, is presented. The areas that need specific attention in the future to bring this technology to the market are discussed, including the issues concerning delivery, safety, compatibility of plasmids in multivalent vaccines and the potential of using immune stimulants as part of a DNA vaccine. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：13 / 28

页数：16

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