Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

被引：296

作者：

Unger, Roger H. ^{[1
,2
]}

Scherer, Philipp E. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Internal Med, Touchstone Ctr Diabet Res, Dallas, TX 75390 USA

[2] Vet Affairs Med Ctr, Dallas, TX 75216 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2010年 / 21卷 / 06期

关键词：

INSULIN-RESISTANCE; TRIGLYCERIDE CONTENT; DIABETES-MELLITUS; BETA-CELLS; FAT; OBESITY; LIPOAPOPTOSIS; HUMANS; HEART; MODEL;

D O I：

10.1016/j.tem.2010.01.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Once considered divine retribution for sins, comorbidities of obesity (metabolic syndrome) are today attributed to obesity-induced metabolic defects. Here, we propose that obesity and hyperleptinemia protect lipid-intolerant nonadipose organs against lipotoxic lipid spillover during sustained caloric surplus. Metabolic syndrome is ascribed to lipotoxicity caused by age-related resistance to antilipotoxic protection by leptin.

引用

收藏

页码：345 / 352

页数：8

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