Feigrisolides A, B, C and D, new lactones with antibacterial activities from Streptomyces griseus

被引：31

作者：

Tang, YQ

Sattler, I

Thiericke, R

Grabley, S

Feng, XZ

机构：

[1] Hans Knoll Inst Nat Stoff Forsch EV, D-07745 Jena, Germany

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

[3] Peking Union Med Coll, Beijing 100050, Peoples R China

来源：

JOURNAL OF ANTIBIOTICS | 2000年 / 53卷 / 09期

关键词：

D O I：

10.7164/antibiotics.53.934

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Four new lactone compounds, named feigrisolides A to D (1 to 4), have been isolated from Streptomyces griseus. The chemical structures were determined by detail analysis of their spectroscopic data and chemical transformations. Structurally, the feigrisolides A (1) and B (2) are hepta-lactones, feigrisolide C (3) and D (4) are 16-membered macrodiolides. Biological studies showed that feigrisolide B (2) exhibited strong antibacterial, as well as medium cyctotoxic, and antiviral activities. Feigrisolides A (1), C (3) and D (4) are medium inhibitors of 3 alpha-hydroxysteroid-dehydrogenase (3 alpha-HSD) inhibiting activity.

引用

页码：934 / 943

页数：10

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