Cdk5 deregulation in the pathogenesis of Alzheimer's disease

被引:216
作者
Cruz, JC [1 ]
Tsai, LH [1 ]
机构
[1] Harvard Univ, Sch Med, Howard Hughes Med Inst, Dept Pathol, Boston, MA 02115 USA
关键词
D O I
10.1016/j.molmed.2004.07.001
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The aberrant metabolism of tau and (beta-amyloid precursor protein (APP) has key roles in the neurodegenerative processes that contribute to the etiology of Alzheimer's disease (AD). These pathological characteristics of AD have recently been linked to the deregulation of cyclin-dependent kinase 5 (cdk5). The finding that the inducible expression of p25, which is the neurotoxic activator of cdk5, triggers progressive neurodegeneration and neurofibrillary tangle formation in mice provides compelling evidence that p25-cdk5 is one of the crucial pathways that can lead to AD pathophysiology. Furthermore, a role for cdk5 in modulating APP processing and (beta-amyloid generation is emerging. Therefore, as one of the molecular links between APP and tau, cdk5 might be a valuable target for therapeutic intervention in AD and other neurodegenerative diseases.
引用
收藏
页码:452 / 458
页数:7
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