Sulfenic acid in human serum albumin

被引:107
作者
Carballal, S.
Alvarez, B.
Turell, L.
Botti, H.
Freeman, B. A.
Radi, R.
机构
[1] Univ Republica, Fac Med, Dept Bioquim, Montevideo 11800, Uruguay
[2] Univ Republica, Fac Ciencias, Lab Enzimol, Montevideo 11800, Uruguay
[3] Univ Republica, Ctr Free Radical & Biomed Res, Montevideo, Uruguay
[4] Univ Pittsburgh, Med Ctr, Dept Pharmacol, Pittsburgh, PA 15260 USA
关键词
thiol; human serum albumin; sulfenic acid; peroxynitrite; hydrogen peroxide; free radicals;
D O I
10.1007/s00726-006-0430-y
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Sulfenic acid (RSOH) is a central intermediate in both the reversible and irreversible redox modulation by reactive species of an increasing number of proteins involved in signal transduction and enzymatic pathways. In this paper we focus on human serum albumin (HSA), the most abundant plasma protein, proposed to serve antioxidant functions in the vascular compartment. Sulfenic acid in HSA has been previously detected using different methods after oxidation of its single free thiol Cys34 through one- or two-electron mechanisms. Since recent evidence suggests that sulfenic acid in HSA is stabilized within the protein environment, this derivative represents an appropriate model to examine protein sulfenic acid biochemistry, structure and reactivity. Sulfenic acid in HSA could be involved in mixed disufide formation, supporting a role of HSA-Cys34 as an important redox regulator in extracellular compartments.
引用
收藏
页码:543 / 551
页数:9
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