Nutrigenomics:: goals and strategies

被引：390

作者：

Müller, M ^{[1
]}

Kersten, S ^{[1
]}

机构：

[1] Univ Wageningen & Res Ctr, Div Human Nutr, NL-6703 HD Wageningen, Netherlands

来源：

NATURE REVIEWS GENETICS | 2003年 / 4卷 / 04期

关键词：

D O I：

10.1038/nrg1047

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Nutrigenomics is the application of high-throughput genomics tools in nutrition research. Applied wisely, it will promote an increased understanding of how nutrition influences metabolic pathways and homeostatic control, how this regulation is disturbed in the early phase of a diet-related disease and to what extent individual sensitizing genotypes contribute to such diseases. Ultimately, nutrigenomics will allow effective dietary-Intervention strategies to recover normal homeostasis and to prevent diet-related diseases.

引用

页码：315 / 322

页数：8

共 100 条

[1] Blood levels of long-chain n-3 fatty acids and the risk of sudden death. [J].

Albert, CM ;

Campos, H ;

Stampfer, MJ ;

Ridker, PM ;

Manson, JE ;

Willett, WC ;

Ma, J .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 346 (15) :1113-1118

[2] Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor [J].

Ananthanarayanan, M ;

Balasubramanian, N ;

Makishima, M ;

Mangelsdorf, DJ ;

Suchy, FJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) :28857-28865

[3] Polymorphisms of methylenetetrahydrofolate reductase and other enzymes: Metabolic significance, risks and impact on folate requirement [J].

Bailey, LB ;

Gregory, JF .

JOURNAL OF NUTRITION, 1999, 129 (05) :919-922

[4] Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis [J].

Barbier, O ;

Torra, IP ;

Duguay, Y ;

Blanquart, C ;

Fruchart, JC ;

Glineur, C ;

Staels, B .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2002, 22 (05) :717-726

[5]

BIANCHARD RK, 2001, P NATL ACAD SCI USA, V98, P13507

[6] Stereotyped and specific gene expression programs in human innate immune responses to bacteria [J].

Boldrick, JC ;

Alizadeh, AA ;

Diehn, M ;

Dudoit, S ;

Liu, CL ;

Belcher, CE ;

Botstein, D ;

Staudt, LM ;

Brown, PO ;

Relman, DA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (02) :972-977

[7] Classical twin studies and beyond [J].

Boomsma, D ;

Busjahn, A ;

Peltonen, L .

NATURE REVIEWS GENETICS, 2002, 3 (11) :872-882

[8]

Bradham CA, 1998, AM J PHYSIOL-GASTR L, V275, pG387, DOI 10.1152/ajpgi.1998.275.3.G387

[9] Association between n-3 fatty acid status in blood and electrocardiographic in predictors of arrhythmia risk healthy volunteers [J].

Brouwer, IA ;

Zock, PL ;

van Amelsvoort, LGPM ;

Katan, MB ;

Schouten, EG .

AMERICAN JOURNAL OF CARDIOLOGY, 2002, 89 (05) :629-+

[10] Genomic profiling of short- and long-term caloric restriction effects in the liver of aging mice [J].

Cao, SX ;

Dhahbi, JM ;

Mote, PL ;

Spindler, SR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (19) :10630-10635

← 1 2 3 4 5 6 7 8 9 10 →