LDL particle subclasses, LDL particle size, and carotid atherosclerosis in the Multi-Ethnic Study of Atherosclerosis (MESA)

被引:281
作者
Mora, Samia
Szklo, Moyses
Otvos, James D.
Greenland, Philip
Psaty, Bruce M.
Goff, David C., Jr.
O'Leary, Daniel H.
Saad, Mohammed F.
Tsai, Michael Y.
Sharrett, A. Richey
机构
[1] Brigham & Womens Hosp, Dept Med, Ctr Cardiovasc Dis Prevent, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[4] LipoSci Inc, Raleigh, NC USA
[5] Northwestern Univ, Feinberg Sch Med, Dept Prevent Med, Chicago, IL 60611 USA
[6] Northwestern Univ, Feinberg Sch Med, Dept Med, Chicago, IL 60611 USA
[7] Univ Washington, Dept Med, Seattle, WA 98195 USA
[8] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA
[9] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA
[10] Wake Forest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27103 USA
[11] Tufts Univ, New England Med Ctr, Dept Radiol, Boston, MA 02111 USA
[12] SUNY Stony Brook, Sch Med, Dept Prevent Med, Stony Brook, NY 11794 USA
[13] Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA
关键词
lipoproteins; lipids; subclinical atherosclerosis; carotid arteries; magnetic resonance spectroscopy;
D O I
10.1016/j.atherosclerosis.2006.05.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Previous studies showing that smaller low-density lipoprotein (LDL) size is associated with greater atherosclerotic risk did not adequately control for small and large LDL particle correlation. Methods and results: We studied the association of lipoproteins measured by proton nuclear magnetic resonance spectroscopy with carotid intima-media thickness (IMT) in apparently healthy individuals (N = 5538, 38% White, 28% African American, 22% Hispanic, 12% Chinese). Small and large LDL particle concentrations (LDL-p) were inversely correlated (r = -0.63, P < 0.0001). Controlling for risk factors but not for LDL subclass correlation, LDL size and small LDL-p separately were associated with IMT (-20.9 and 31.7 mu m change in IMT per 1-S.D., respectively, both P < 0.001), but large LDL-p was not (4.9 mu m, P = 0.27). When LDL subclasses were included in the same model, large and small LDL-p were both associated with IMT (36.6 and 52.2 mu m higher IMT per 1-S.D., respectively, both P < 0.001; 17.7 and 11.6 mu m per 100 nmol/L, respectively). LDL size was not significant after accounting for LDL subclasses and risk factors (P = 0.10). Conclusion: Both LDL subclasses were significantly associated with subclinical atherosclerosis, with small LDL confounding the association of large LDL with atherosclerosis. Future studies of LDL size should account for the strong inverse correlation of LDL subclasses. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:211 / 217
页数:7
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