Synthesis of a rhazinilam analogue acting as an inhibitor of tubulin assembly

被引：22

作者：

Dupont, C ^{[1
]}

Guénard, D ^{[1
]}

Thal, C ^{[1
]}

Thoret, S ^{[1
]}

Guéritte, F ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 31期

关键词：

rhazinilam; phenylpyrroles; coupling reactions; biological activity tubulin;

D O I：

10.1016/S0040-4039(00)00983-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of a di-nor-secorhazinilam analogue is described. This phenylpyrrole compound has been prepared by a Susuki cross-coupling reaction between 1,2,5 trisubstituted pyrrole halides and 2-N-(tertbutoxycarbonyl)aminophenyl boronic acid. In contrast to rhazinilam, this new phenylpyrrole inhibits the assembly of tubulin into microtubules. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5853 / 5856

页数：4

共 18 条

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