Synthesis of cyclic peptides from unprotected precursors using removable Nα-(1-(4-methoxyphenyl)-2-mercaptoethyl) auxiliary

被引：18

作者：

Cardona, VMF ^{[1
]}

Hartley, O ^{[1
]}

Botti, P ^{[1
]}

机构：

[1] Univ Geneva, Ctr Med, Dept Med Biochem, CH-1211 Geneva, Switzerland

来源：

JOURNAL OF PEPTIDE RESEARCH | 2003年 / 61卷 / 03期

关键词：

chemical ligation; peptide cyclization; solid-phase synthesis;

D O I：

10.1034/j.1399-3011.2003.00043.x

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A new method to cyclize unprotected peptides is presented. The method involves the use of a 1-phenyl-2-mercaptoethyl derivative on the N-terminal glycine. This template acts as an auxiliary thiol-containing group in order to drive cyclization with a counterpart thioester moiety on the same molecule. Subsequent facile removal of the derivative generates products with only native peptide structure. The successful, high-yield cyclization of the peptide GSPYSSDTTPA is described.

引用

页码：152 / 157

页数：6

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