Rab cascades and tethering factors in the endomembrane system

被引：93

作者：

Markgraf, Daniel F. ^{[1
]}

Peplowska, Karolina ^{[1
]}

Ungermann, Christian ^{[1
]}

机构：

[1] Univ Osnabruck, Dept Biol, Biochem Sect, D-49076 Osnabruck, Germany

来源：

FEBS LETTERS | 2007年 / 581卷 / 11期

关键词：

Rab GTPases; tethering factor; rab effector; vesicular transport; endomembrane; Rab cascade;

D O I：

10.1016/j.febslet.2007.01.090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2125 / 2130

页数：6

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