Rab cascades and tethering factors in the endomembrane system

被引：93

作者：

Markgraf, Daniel F. ^{[1
]}

Peplowska, Karolina ^{[1
]}

Ungermann, Christian ^{[1
]}

机构：

[1] Univ Osnabruck, Dept Biol, Biochem Sect, D-49076 Osnabruck, Germany

来源：

FEBS LETTERS | 2007年 / 581卷 / 11期

关键词：

Rab GTPases; tethering factor; rab effector; vesicular transport; endomembrane; Rab cascade;

D O I：

10.1016/j.febslet.2007.01.090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rab GTPases are key proteins that determine organelle identity and operate at the center of fusion reactions. Like Ras, they act as switches that are connected to a diverse network of tethering factors, exchange factors and GTPase activating proteins. Recent studies suggest that Rabs are linked to each other via their effectors, thus coordinating protein transport in the endomembrane system. Within this review, we will focus on selected examples that highlight these issues. (C) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：2125 / 2130

页数：6

共 57 条

[31] Targeting RAB GTPases to distinct membrane compartments
Pfeffer, S
Aivazian, D
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (11) : 886 - 896
[32] Membrane domains in the secretory and endocytic pathways
Pfeffer, S
[J]. CELL, 2003, 112 (04) : 507 - 517
[33] Rab GTPases: specifying and deciphering organelle identity and function
Pfeffer, SR
[J]. TRENDS IN CELL BIOLOGY, 2001, 11 (12) : 487 - 491
[34] Rab conversion as a mechanism of progression from early to late endosomes
Rink, J
Ghigo, E
Kalaidzidis, Y
Zerial, M
[J]. CELL, 2005, 122 (05) : 735 - 749
[35] Higher order Rab programming in phagolysosome biogenesis
Roberts, Esteban A.
Chua, Jennifer
Kyei, George B.
Deretic, Vojo
[J]. JOURNAL OF CELL BIOLOGY, 2006, 174 (07) : 923 - 929
[36] TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion
Sacher, M
Jiang, Y
Barrowman, J
Scarpa, A
Burston, J
Zhang, L
Schieltz, D
Yates, JR
Abeliovich, H
Ferro-Novick, S
[J]. EMBO JOURNAL, 1998, 17 (09) : 2494 - 2503
[37] TRAPP I implicated in the specificity of tethering in ER-to-Golgi transport
Sacher, M
Barrowman, J
Wang, W
Horecka, J
Zhang, YY
Pypaert, M
Ferro-Novick, S
[J]. MOLECULAR CELL, 2001, 7 (02) : 433 - 442
[38] A Ypt/Rab effector complex containing the Sec1 homolog Vps33p is required for homotypic vacuole fusion
Seals, DF
Eitzen, G
Margolis, N
Wickner, WT
Price, A
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (17) : 9402 - 9407
[39] SEGEV N, 2001, SCI STKE, pRE11, DOI DOI 10.1126/STKE.2001.100.RE11
[40] Golgins and GTPases, giving identity and structure to the Golgi apparatus
Short, B
Haas, A
Barr, FA
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2005, 1744 (03): : 383 - 395

← 1 2 3 4 5 6 →