An efficient asymmetric synthesis of key intermediates in the synthesis of aphanorphine and eptazocine

被引：29

作者：

Taylor, SK ^{[1
]}

Ivanovic, M ^{[1
]}

Simons, LJ ^{[1
]}

Davis, MM ^{[1
]}

机构：

[1] Hope Coll, Dept Chem, Holland, MI 49422 USA

来源：

TETRAHEDRON-ASYMMETRY | 2003年 / 14卷 / 06期

关键词：

D O I：

10.1016/S0957-4166(03)00117-4

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Efficient, formal syntheses of aphanorphine and eptazocine are reported that involve epoxide cyclizations. The necessary chiral epoxides were prepared following treatment of diols prepared by Sharpless asymmetric osmylations of an alkene. The cyclizations formed a ring compound with the same enantiomeric purity as the starting epoxide. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：743 / 747

页数：5

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