MHC Class I: An Unexpected Role in Neuronal Plasticity

被引:270
作者
Shatz, Carla J. [1 ,2 ]
机构
[1] Stanford Univ, James H Clark Ctr, Dept Biol, Stanford, CA 94305 USA
[2] Stanford Univ, James H Clark Ctr, Dept Neurobiol, Stanford, CA 94305 USA
关键词
MAJOR HISTOCOMPATIBILITY COMPLEX; CENTRAL-NERVOUS-SYSTEM; OCULAR-DOMINANCE PLASTICITY; DEVELOPING VISUAL-CORTEX; FRAGILE-X-SYNDROME; SYNAPTIC PLASTICITY; GENE-EXPRESSION; COMMON VARIANTS; MESSENGER-RNAS; MOUSE MODEL;
D O I
10.1016/j.neuron.2009.09.044
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
For the nervous system to translate experience into memory and behavior, lasting structural change at synapses must occur. This requirement is clearly evident during critical periods of activity-dependent neural development, and accumulating evidence has established a surprising role for the major histocompatibility complex class I (MHCI) proteins in this process.
引用
收藏
页码:40 / 45
页数:6
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