Disordered regulation of coagulation and platelet activation in xenotransplantation

被引:124
作者
Robson, SC
Cooper, DKC
d'Apice, AJF
机构
[1] Harvard Univ, Sch Med, Dept Med, Newark Beth Israel Med Ctr, Boston, MA USA
[2] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Transplantat Biol Res Ctr, Boston, MA USA
[3] St Vincents Hosp, Immunol Res Ctr, Melbourne, Vic 3065, Australia
关键词
coagulation; endothelial cells; molecular incompatibility; platelets; xenotransplantation;
D O I
10.1034/j.1399-3089.2000.00067.x
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Rejection of xenografts is associated with vascular-based inflammation, thrombocytopenia and the consumption of coagulation factors that may evolve into disseminated intravascular coagulation (DIC). Similarly, bone marrow-derived cellular xenotransplantation procedures are associated with endothelial cell activation and thrombotic microangiopathic injury. These complications generally develop despite the best available measures for depletion of xenoreactive natural antibody, inhibition of complement activation and suppression of T- and B-cell mediated immune responses. The mechanisms underlying the DIC and thrombotic microangiopathy associated with xenotransplantation are unclear. A proposed primary biological dysfunction of xenografts with respect to regulation of clotting could amplify vascular injury, promote immunological responses and independently contribute to graft failure. Disordered thromboregulation could have deleterious effects, comparable to unregulated complement activation, in the pathogenesis of xenograft rejection and may therefore represent a substantive barrier to xenotransplantation.
引用
收藏
页码:166 / 176
页数:11
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