Controlling the Particle Size of Interpolymer Complexes through Host-Guest Interaction for Drug Delivery

被引：30

作者：

Chen, Yan ^{[1
]}

Pang, Yan ^{[1
]}

Wu, Jieli ^{[4
]}

Su, Yue ^{[1
]}

Liu, Jinyao ^{[1
]}

Wang, Ruibin ^{[4
]}

Zhu, Bangshang ^{[4
]}

Yao, Yefeng ^{[2
,3
]}

Yan, Deyue ^{[1
]}

Zhu, Xinyuan ^{[1
,4
]}

Chen, Qun ^{[2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China

[2] E China Normal Univ, Dept Phys, Shanghai 200062, Peoples R China

[3] E China Normal Univ, Shanghai Key Lab Funct Magnet Resonance Imaging, Shanghai 200062, Peoples R China

[4] Shanghai Jiao Tong Univ, Instrumental Anal Ctr, Shanghai 200240, Peoples R China

来源：

LANGMUIR | 2010年 / 26卷 / 11期

基金：

中国国家自然科学基金;

关键词：

INCLUSION COMPLEXES; POLY(ETHYLENE GLYCOL); POLY(ACRYLIC ACID); ALPHA-CYCLODEXTRIN; POLYROTAXANE; COPOLYMER; MEMBRANES; POLYMERS; PHASE;

D O I：

10.1021/la9048133

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new method to adjust the particle size of interpolymer complexes has been developed by introduction of host-guest interaction into the dilute aqueous solution of poly(acrylic acid) (PAA) and poly(ethylene glycol) (PEG). Because of the cooperative hydrogen-bonding interaction, PAA can form the interpolymer complexes with PEG. Putting beta-cyclodextrin (beta-CD) into dilute PAA/PEG aqueous solution, the competition between host-guest and hydrogen-bonding interactions happens. The beta-CD/PAA/PEG ternary systems have been well characterized by ultraviolet-visible absorption spectroscopy (UV-vis), dynamic light scattering (DLS), transmission electron microscopy (TEM), diffusion NMR spectroscopy, attenuated total reflectance-Fourier transform infrared (ATR-FTIR), and solid-state C-13 NM R spectroscopy. The results indicate that the hydrophobic cavity of beta-CD is threaded by linear polymers so that the hydrophilicity of PAA/PEG interpolymer complexes is improved greatly. Adjusting the amounts of beta-CD, the particle size of the interpolymer complexes can be readily controlled. The low cytotoxicity of various beta-CD/PAA/PEG ternary complexes has been confirmed using the MTT assay in COS-7 cell line. Doxorubicin (DOX), an anticancer drug, has been encapsulated into the beta-CD/PAA/PEG ternary complexes. The DOX-loaded beta-CD/PAA/PEG ternary complexes have been analyzed by confocal laser scanning microscopy (CLSM), flow cytometry analysis, and the MTT assay against human cervical carcinoma cell (Hela). The results indicate that beta-CD/PAA/PEG ternary complexes with controlled particle size could be used as safe and promising drug carriers.

引用

页码：9011 / 9016

页数：6

共 37 条

[1] SOME FACTORS AFFECTING MOLECULAR ASSOCIATION OF POLY(ETHYLENE OXIDE) + POLY)ACRYLIC ACID) IN AQUEOUS SOLUTION [J].