Why is transcription coupled to translation in bacteria?

被引:107
作者
Gowrishankar, J [1 ]
Harinarayanan, R [1 ]
机构
[1] Ctr DNA Fingerprinting & Diagnost, Lab Bacterial Genet, Hyderabad 500076, Andhra Pradesh, India
关键词
D O I
10.1111/j.1365-2958.2004.04289.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Active mechanisms exist to prevent transcription that is uncoupled from translation in the protein-coding genes of bacteria, as exemplified by the phenomenon of nonsense polarity. Bacterial transcription-translation coupling may be viewed as one among several co-transcriptional processes, including those for mRNA processing and export in the eukaryotes, that operate in the various life forms to render the nascent transcript unavailable for formation of otherwise deleterious R-loops in the genome.
引用
收藏
页码:598 / 603
页数:6
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