Why is transcription coupled to translation in bacteria?

被引：107

作者：

Gowrishankar, J ^{[1
]}

Harinarayanan, R ^{[1
]}

机构：

[1] Ctr DNA Fingerprinting & Diagnost, Lab Bacterial Genet, Hyderabad 500076, Andhra Pradesh, India

来源：

MOLECULAR MICROBIOLOGY | 2004年 / 54卷 / 03期

关键词：

D O I：

10.1111/j.1365-2958.2004.04289.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Active mechanisms exist to prevent transcription that is uncoupled from translation in the protein-coding genes of bacteria, as exemplified by the phenomenon of nonsense polarity. Bacterial transcription-translation coupling may be viewed as one among several co-transcriptional processes, including those for mRNA processing and export in the eukaryotes, that operate in the various life forms to render the nascent transcript unavailable for formation of otherwise deleterious R-loops in the genome.

引用

页码：598 / 603

页数：6

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