Inhibitors of Akt activity

被引：3

作者：

Lippa, Blaise ^{[1
]}

机构：

[1] Pfizer Inc PGD Groton, Groton, CT 06340 USA

来源：

EXPERT OPINION ON THERAPEUTIC PATENTS | 2007年 / 17卷 / 05期

关键词：

4-amino-1,2,5-oxadiazole; Akt antagonist; imidazo[4,5-c] pyridine; PKB;

D O I：

10.1517/13543776.17.5.577

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Imidazo[4,5-c]pyridine analogs with Akt (PKB) kinase antagonist activity are claimed. The compounds contain a 4-amino-1,2,5-oxadiazole substituent at the 2-position of the ring system with an alkyne substituent at the 4-position, and diverse functionality at the 6-position. The compounds are indicated to be useful in the treatment of cancer and arthritis.

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页码：577 / 581

页数：5

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