Structure of poly (dT)•poly (dA)•poly (dT)

被引：9

作者：

Chandrasekaran, R ^{[1
]}

Giacometti, A ^{[1
]}

Arnott, S ^{[1
]}

机构：

[1] Purdue Univ, Whistler Ctr Carbohydrate Res, W Lafayette, IN 47907 USA

来源：

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2000年 / 17卷 / 06期

关键词：

D O I：

10.1080/07391102.2000.10506589

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The molecular structure of poly (dT).poly (dA).poly (dT) has been determined and refined using the continuous x-ray intensity data on layer lines in the diffraction pattern obtained from an oriented fiber of the DNA. The final R-value for the preferred structure is 0.29 significantly lower than that for plausible alternatives. The molecule forms a 12-fold right-handed triple-helix of pitch 38.4 Angstrom and each base tripler is stabilized by a set of four Crick-Watson-Hoogsteen hydrogen bonds. The deoxyribose rings in all the three strands have C2'-endo conformations. The grooveless cylindrical shape of the triple-helix is consistent with the lack of lateral organization in the fiber.

引用

页码：1011 / 1022

页数：12

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