Phytochemical flavones isolated from Scutellaria barbata and antibacterial activity against methicillin-resistant Staphylococcus aureus

被引：197

作者：

Sato, Y

Suzaki, S

Nishikawa, T

Kihara, M

Shibata, H

Higuti, T

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Lab Microbial Chem, Tokushima 7708505, Japan

[2] Alps Pharmaceut Ind Co Ltd, Gifu 5094241, Japan

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2000年 / 72卷 / 03期

关键词：

Scutellaria barbata; antibacterial activity; apigenin; luteolin; methicillin-resistant Staphylococcus aureus;

D O I：

10.1016/S0378-8741(00)00265-8

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A crude extract prepared from Scutellaria barbata D. Don (Lamiaceae) was analyzed in the effort to discover antibacterial compounds against high-level strains of methicillin-resistant Staphylococcus aureus (MRSA). Apigenin and luteolin were isolated from the plant as active constituents against the bacteria. These flavonoid congeners were selectively toxic to S. aureus, including the MRSA and methicillin-sensitive S. aureus strains. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

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页码：483 / 488

页数：6

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