CYTOTOXIC CONSTITUENTS OF BACCHARIS-GAUDICHAUDIANA

被引：49

作者：

FULLAS, F ^{[1
]}

HUSSAIN, RA ^{[1
]}

CHAI, HB ^{[1
]}

PEZZUTO, JM ^{[1
]}

SOEJARTO, DD ^{[1
]}

KINGHORN, AD ^{[1
]}

机构：

[1] UNIV ILLINOIS,COLL PHARM,DEPT MED CHEM & PHARMACOGNOSY,PROGRAM COLLABORAT RES PHARMACEUT SCI,CHICAGO,IL 60612

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 06期

关键词：

D O I：

10.1021/np50108a017

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new labdane diterpenes, gaudichaudols A-C [1-3], a new clerodane diterpenoid, gaudichaudone [4], and the known clerodane, articulin acetate [5] have been isolated from the aerial parts of Baccharis gaudichaudiana, together with the known compounds, apigenin, hispidulin, spathulenol, and ursolic acid. Through the application of 1D- and 2D nmr spectroscopy, the structures of the new diterpenoids [1-4] were, in turn, elucidated as 15,16,18,19-tetrahydroxylabd-5-ene,15-O-acetyl-16,18,19-trihydroxylabd-5-ene,16-O-p-trans-coumaroyl-15,18,19-trihydroxylabd-5-ene, and 2 beta-hydroxy-15,16-epoxycleroda-1(10),15,16-trien-18,19-olide. The isolated compounds were evaluated in P-388 lymphocytic leukemia cells as well as a battery of human cancer cell lines. Among the diterpenoids, gaudichaudol C [3], gaudichaudone [4], and articulin acetate [5] exhibited significant cytotoxic activity against certain cancer cells.

引用

页码：801 / 807

页数：7

共 21 条

[1] URSANE TRITERPENOIDS FROM NEPETA-ERIOSTACHIA [J].