Biology of chronic myelogenous leukemia

被引：40

作者：

Verfaillie, CM

机构：

[1] Univ Minnesota, Dept Med, Stem Cell Biol Program, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1998年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0889-8588(05)70495-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This article reviews the biology of chronic myelogenous leukemia (CML) and its effect on the process of hematopoiesis. The relevance of the BCR-ABL fusion protein as well as murine models are also discussed. CML has been studied more extensively than any other malignancy, yet the correlation between the clinical symptoms of chronic phase CML and the BCR-ABL oncoprotein is poorly understood. Insights from recent efforts both to develop a good in vivo animal model and to characterize the effect of the BCR-ABL oncoprotein on relevant signal molecules may lead to a better understanding of the pathophysiology of chronic phase CML and, thereby, to the development of targeted therapeutic approaches.

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页码：1 / +

页数：30

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