Biology of chronic myelogenous leukemia

被引：40

作者：

Verfaillie, CM

机构：

[1] Univ Minnesota, Dept Med, Stem Cell Biol Program, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 1998年 / 12卷 / 01期

关键词：

D O I：

10.1016/S0889-8588(05)70495-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This article reviews the biology of chronic myelogenous leukemia (CML) and its effect on the process of hematopoiesis. The relevance of the BCR-ABL fusion protein as well as murine models are also discussed. CML has been studied more extensively than any other malignancy, yet the correlation between the clinical symptoms of chronic phase CML and the BCR-ABL oncoprotein is poorly understood. Insights from recent efforts both to develop a good in vivo animal model and to characterize the effect of the BCR-ABL oncoprotein on relevant signal molecules may lead to a better understanding of the pathophysiology of chronic phase CML and, thereby, to the development of targeted therapeutic approaches.

引用

收藏

页码：1 / +

页数：30

相关论文

共 215 条

[41] TRANSFORMATION OF AN INTERLEUKIN-3-DEPENDENT HEMATOPOIETIC-CELL LINE BY THE CHRONIC MYELOGENOUS LEUKEMIA-SPECIFIC P210BER/ABL PROTEIN [J].

DALEY, GQ ;

BALTIMORE, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (23) :9312-9316

[42] INDUCTION OF CHRONIC MYELOGENOUS LEUKEMIA IN MICE BY THE P210BCR/ABL GENE OF THE PHILADELPHIA-CHROMOSOME [J].

DALEY, GQ ;

VANETTEN, RA ;

BALTIMORE, D .

SCIENCE, 1990, 247 (4944) :824-830

[43] NONMYRISTOYLATED ABL PROTEINS TRANSFORM A FACTOR-DEPENDENT HEMATOPOIETIC-CELL LINE [J].

DALEY, GQ ;

VANETTEN, RA ;

JACKSON, PK ;

BERNARDS, A ;

BALTIMORE, D .

MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (04) :1864-1871

[44] BLAST CRISIS IN A MURINE MODEL OF CHRONIC MYELOGENOUS LEUKEMIA [J].

DALEY, GQ ;

VANETTEN, RA ;

BALTIMORE, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11335-11338

[45]

DALEY GQ, 1993, EXP HEMATOL, V21, P734

[46] JAK-STAT SIGNALING INDUCED BY THE V-ABL ONCOGENE [J].

DANIAL, NN ;

PERNIS, A ;

ROTHMAN, PB .

SCIENCE, 1995, 269 (5232) :1875-1877

[47] TRANSCRIPTIONAL REGULATION BY MAP KINASES [J].

DAVIS, RJ .

MOLECULAR REPRODUCTION AND DEVELOPMENT, 1995, 42 (04) :459-467

[48] INTERACTION OF THE SEED AND THE SOIL [J].

DEISSEROTH, AB ;

KOENIG, J .

JOURNAL OF CLINICAL INVESTIGATION, 1994, 94 (01) :3-3

[49] CRKL IS COMPLEXED WITH TYROSINE-PHOSPHORYLATED CBL IN PH-POSITIVE LEUKEMIA [J].

DEJONG, R ;

TENHOEVE, J ;

HEISTERKAMP, N ;

GROFFEN, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (37) :21468-21471

[50] EXPRESSION OF ADHESION MOLECULES ON CD34(+) CELLS - CD34(+) L-SELECTIN(+) CELLS PREDICT A RAPID PLATELET RECOVERY AFTER PERIPHERAL-BLOOD STEM-CELL TRANSPLANTATION [J].

DERCKSEN, MW ;

GERRITSEN, WR ;

RODENHUIS, S ;

DIRKSON, MKA ;

SLAPERCORTENBACH, ICM ;

SCHAASBERG, WP ;

PINEDO, HM ;

VONDEMBORNE, AEGK ;

VANDERSCHOOT, CE .

BLOOD, 1995, 85 (11) :3313-3319

← 1 2 3 4 5 6 7 8 9 10 →