Biologically active quassinoids and their chemistry: Potential leads for drug design

被引：120

作者：

Guo, Z

Vangapandu, S

Sindelar, RW

Walker, LA

Sindelar, RD ^{[1
]}

机构：

[1] Univ British Columbia, Fac Pharmaceut Sci, Vancouver, BC V6T 1Z3, Canada

[2] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Appl Drug Design & Synth, University, MS 38677 USA

[4] Univ Mississippi, Sch Pharm, Dept Chem, University, MS 38677 USA

[5] Univ Mississippi, Sch Pharm, Natl Ctr Dev Nat Prod, University, MS 38677 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2005年 / 12卷 / 02期

关键词：

quassinoids; semi-synthesis; total synthesis; biological activities; SAR; antileukemic and antimalarial activities;

D O I：

10.2174/0929867053363351

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Quassinoids are highly oxygenated triterpenes, which were isolated as bitter principles from the plants of Simaroubaceae family. Their synthesis has attracted much attention because of the wide spectrum of their biological properties. The most prevalent quassinoids have C-20 picrasane skeleton, some known as bruceolides as they were isolated from the genus Brucea, which showed marked antileukemic and antimalarial activities.

引用

页码：173 / 190

页数：18

共 114 条

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INVITRO CYTOTOXICITY OF A SERIES OF QUASSINOIDS FROM BRUCEA-JAVA']JAVANICA FRUITS AGAINST KB CELLS [J].