Cu-FeCl3-mediated one-pot multicomponent reaction leading to N-aryl- and N-alkyltriazoles in water

被引：37

作者：

Saba, Biswajit ^{[1
]}

Sharma, Sunil ^{[1
]}

Sawant, Devesh ^{[1
]}

Kundu, Bijoy ^{[1
]}

机构：

[1] Cent Drug Res Inst, Div Med Chem, Lucknow 226001, Uttar Pradesh, India

来源：

SYNLETT | 2007年 / 10期

关键词：

multicomponent reaction; triazole; Cu-FeCl3; redox reaction;

D O I：

10.1055/s-2007-982543

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise, convenient and mild route for the one-pot syntheses of N-aryl- and N-alkyltriazoles in water is reported, The methodology involves the three-component reaction comprising phenylacetylene, sodium azide and aryl/alkyl halide catalyzed by Cu(l) species generated in situ by a redox reaction between FeCl3 and copper metal. Prominent features of our methodology are incorporation of aryl fluoride to generate N-aryltriazoles, which are rather scarcely reported, use of water as reaction medium, and avoidance of hazardous aryl azide as a reactant.

引用

页码：1591 / 1594

页数：4

共 37 条

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