Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano- and Microparticles

被引：266

作者：

He, Qianjun ^{[1
]}

Zhang, Zhiwen ^{[2
]}

Gao, Yu ^{[2
]}

Shi, Jianlin ^{[1
]}

Li, Yaping ^{[2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

来源：

SMALL | 2009年 / 5卷 / 23期

关键词：

cytotoxicity; intracellular localization; mesoporous silica; microparticles; spherical nanoparticles; DRUG-DELIVERY; CONTROLLED-RELEASE; NANOPARTICLES; TOXICITY; MICELLES; SURFACE; CRYSTALLINE; MECHANISMS; PARTICLES; LIPOSOMES;

D O I：

10.1002/smll.200900923

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano- and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano- and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.

引用

页码：2722 / 2729

页数：8

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