Protective effect of salivary nitrate and microbial nitrate reductase activity against caries

被引：98

作者：

Doel, JJ

Hector, MP

Amirtham, CV

Al-Anzan, LA

Benjamin, N

Allaker, RP

机构：

[1] Barts & London Queen Marys Sch Med & Dent, Oral Microbiol Unit, London E1 2AD, England

[2] Peninsula Med Sch, Exeter, Devon, England

[3] Barts & London Queen Marys Sch Med & Dent, Dept Oral Growth & Dev, London E1 2AD, England

来源：

EUROPEAN JOURNAL OF ORAL SCIENCES | 2004年 / 112卷 / 05期

关键词：

dental caries; diet; nitrate; nitric oxide; Streptococcus mutans;

D O I：

10.1111/j.1600-0722.2004.00153.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

To test the hypothesis that a combination of high salivary nitrate and high nitrate-reducing capacity are protective against dental caries, 209 children attending the Dental Institute, Barts and The London NHS Trust were examined. Salivary nitrate and nitrite levels, counts of Streptococcus mutans and Lactobacillus spp., and caries experience were recorded. Compared with control subjects, a significant reduction in caries experience was found in patients with high salivary nitrate and high nitrate-reducing ability. Production of nitrite from salivary nitrate by commensal nitrate-reducing bacteria may limit the growth of cariogenic bacteria as a result of the production of antimicrobial oxides of nitrogen, including nitric oxide.

引用

页码：424 / 428

页数：5

共 27 条

[1] PREVALENCE OF EIKENELLA-CORRODENS AND ACTINOBACILLUS-ACTINOMYCETEMCOMITANS IN THE DENTAL PLAQUE OF DOGS [J].