Production of first generation adenovirus vectors: a review

被引:142
作者
Danthinne, X
Imperiale, MJ
机构
[1] Univ Michigan, Sch Med, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Ctr Gene Therapy, Ann Arbor, MI 48109 USA
[3] OD 260 Inc, Mt States Med Res Inst, Boise, ID USA
[4] VA Med Ctr, Boise, ID USA
关键词
adenovirus; E1; viral vectors; gene therapy; methods;
D O I
10.1038/sj.gt.3301301
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In the past decade, adenovirus vectors have generated tremendous interest, especially in gene therapy applications. In the so-called 'first generation' adenovirus vectors, the transgenes are inserted in place of the El region, or less often the E3 region. Although second-generation and helper-dependent adenovirus vectors will probably prevail in the future in applications that require long-term gene expression, first generation adenovirus vectors will remain very useful in other settings, such as cancer and vaccination, or simply to transfect cell lines that are refractory to other transfection methods. Until a few years ago, the construction of first generation adenovirus vectors was a labor-intensive and timeconsuming process. More than 20 methods have appeared that facilitate their construction and are reviewed below.
引用
收藏
页码:1707 / 1714
页数:8
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