Optical pH, oxygen and carbon dioxide monitoring using a microdialysis approach

被引：38

作者：

Cooney, CG ^{[1
]}

Towe, BC ^{[1
]}

Eyster, CR ^{[1
]}

机构：

[1] Arizona State Univ, Dept Chem Bio & Mat Engn, Bioengn Program, Coll Engn, Tempe, AZ 85287 USA

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2000年 / 69卷 / 1-2期

基金：

美国国家航空航天局;

关键词：

absorbance; blood gas; fluorescence; microdialysis; micro-flow and optical monitoring;

D O I：

10.1016/S0925-4005(00)00544-X

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Microdialysis coupled with optical absorbance or fluorescence measurement has been used to monitor pH, pCO(2), and pO(2) in blood and buffer solutions. The system employs micro-flow streams of reagents, a simple optical system and a method of achieving steady microliter per minute flow rates. When integrated in a recirculating flow loop, the sensor has an excellent resolution in the physiologic range in buffer of +/-0.003 pH units, +/-0.5 mm Hg pCO(2), and +/-1.5 mm Hg pO(2) with response times in heparinized bovine blood of 4.8 min, 1.8 min, and 2.1 min for pH, pCO(2), and pO(2), respectively. (C) 2000 Elsevier Science S.A. All rights reserved.

引用

页码：183 / 188

页数：6

共 22 条

[1] MEASUREMENT OF SODIUM-HYDROXIDE CONCENTRATION WITH A RENEWABLE REAGENT-BASED FIBEROPTIC SENSOR [J].

BERMAN, RJ ;

CHRISTIAN, GD ;

BURGESS, LW .

ANALYTICAL CHEMISTRY, 1990, 62 (19) :2066-2071

[2]

BOLINDER J, 1992, MICRODIALYSIS MEASUR

[3]

BROWN ML, 1998, THESIS ARIZONA STATE

[4] Intravascular carbon dioxide monitoring using micro-flow colorimetry [J].

Cooney, CG ;

Towe, BC .

BIOSENSORS & BIOELECTRONICS, 1997, 12 (01) :11-17

[5] MEASUREMENT OF SEAWATER PCO2 USING A RENEWABLE-REAGENT FIBER OPTIC SENSOR WITH COLORIMETRIC DETECTION [J].

DEGRANDPRE, MD .

ANALYTICAL CHEMISTRY, 1993, 65 (04) :331-337

[6] Evaluation of an on-demand, ex vivo bedside blood gas monitor on pulmonary artery blood gas determinations [J].

Franklin, ML ;

Peruzzi, WT ;

Moen, SG ;

Shapiro, BA .

ANESTHESIA AND ANALGESIA, 1996, 83 (03) :500-504

[7] OPTICAL FLUORESCENCE AND ITS APPLICATION TO AN INTRAVASCULAR BLOOD-GAS MONITORING-SYSTEM [J].

GEHRICH, JL ;

LUBBERS, DW ;

OPITZ, N ;

HANSMANN, DR ;

MILLER, WW ;

TUSA, JK ;

YAFUSO, M .

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 1986, 33 (02) :117-132

[8] DEVELOPMENT OF A MINIATURIZED GLUCOSE MONITORING-SYSTEM BY COMBINING A NEEDLE-TYPE GLUCOSE SENSOR WITH MICRODIALYSIS SAMPLING METHOD - LONG-TERM SUBCUTANEOUS TISSUE GLUCOSE MONITORING IN AMBULATORY DIABETIC-PATIENTS [J].

HASHIGUCHI, Y ;

UEMURA, T ;

SAKAKIDA, M ;

KAJIWARA, K ;

NISHIDA, K ;

SHICHIRI, M .

DIABETES CARE, 1994, 17 (05) :387-396

[9] CHARACTERIZATION BY MICRODIALYSIS OF INTERCELLULAR GLUCOSE LEVEL IN SUBCUTANEOUS TISSUE IN HUMANS [J].

JANSSON, PA ;

FOWELIN, J ;

SMITH, U ;

LONNROTH, P .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 255 (02) :E218-E220

[10] DUAL-ANALYTE FIBEROPTIC SENSOR FOR THE SIMULTANEOUS AND CONTINUOUS MEASUREMENT OF GLUCOSE AND OXYGEN [J].

LI, L ;

WALT, DR .

ANALYTICAL CHEMISTRY, 1995, 67 (20) :3746-3752

← 1 2 3 →