Translational control of development in C-elegans

被引:19
作者
Goodwin, EB
Evans, TC
机构
[1] Northwestern Univ, Sch Med, Dept Cell & Mol Biol, Chicago, IL 60611 USA
[2] Northwestern Univ, Sch Med, Lurie Canc Ctr, Chicago, IL 60611 USA
[3] Univ Colorado, Hlth Sci Ctr, Dept Cell & Struct Biol, Denver, CO 80262 USA
基金
美国国家卫生研究院;
关键词
translational control; 3 ' UTR; C-elegans; sex determination; heterochronic genes;
D O I
10.1006/scdb.1997.0180
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Translational control by the 3'untranslated reg-ions (3'UTRs) of mRNAs contributes to important events throughout the development of C. elegans. In oocytes and early embryos, maternal mRNAs are controlled by 3'UTR elements to restrict translation of their protein products to specific blastomeres. Localized translation is probably critical for specifying blastomere identity. In both germline and somatic cells, mRNAs from sex determining genes are translationally repressed by 3'UTR controls. These controls balance the activities that specific male and female cell fates. During larval development, the temporal sequence of cell lineages requires 3'UTR-mediated regulation of heterochronic genes by a small non-protein coding RNA. We review what is known about these translational control mechanisms in C. elegans. This overview illustrates that translational control by 3'UTR elements is a powerful mechanism for regulating the expression of multiple gene products in diverse cell types during development of a multi-cellular animal. (C) 1997 Academic Press Ltd.
引用
收藏
页码:551 / 559
页数:9
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