Virus dynamics: the effect of target cell limitation and immune responses on virus evolution

被引：81

作者：

Regoes, RR ^{[1
]}

Wodarz, D ^{[1
]}

Nowak, MA ^{[1
]}

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

来源：

JOURNAL OF THEORETICAL BIOLOGY | 1998年 / 191卷 / 04期

基金：

英国惠康基金;

关键词：

D O I：

10.1006/jtbi.1997.0617

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Earlier models of virus evolution during single infections do not include target cell limitation. Here we extend the basic mathematical framework of these theories and study the effect of target cell limitation on the evolution of antigenic variation, increasing replication rates and increasing virus load. We find that target cell limitation provides a selection pressure against antigenic diversification, and can therefore provide a limit to diversity. Antigenic diversity increases virus load; at the maximum level of antigenic diversity, virus load, too, is at a maximum. (C) 1998 Academic Press Limited.

引用

页码：451 / 462

页数：12

共 45 条

[1]

ANDERSON RM, 1989, CELL TO CELL SIGNALLING : FROM EXPERIMENTS TO THEORETICAL MODELS, P335

[2]

ASJO B, 1986, LANCET, V2, P660

[3]

BITTNER B, 1997, IN PRESS B MATH BIOL

[4] Virus dynamics and drug therapy [J].